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Updated: Apr 8, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
[Positron-emission tomography in urooncology]
T Maurer1, H Kübler, J E Gschwend
1Urologische Klinik und Poliklinik, Technische Universität München, Klinikum rechts der Isar, Ismaninger Straße 22, 81671, München, Deutschland, t.maurer@lrz.tum.de.
Positron emission tomography (PET) shows promise in diagnosing urological cancers. While limited for kidney and bladder cancers, new tracers like (68)Ga-PSMA-PET are revolutionizing prostate cancer imaging.
Area of Science:
- Uro-oncology
- Nuclear Medicine
- Medical Imaging
Background:
- Positron emission tomography (PET) is an established diagnostic tool for urological malignancies.
- Various tracers exist for metabolic information or molecular target detection.
- Current guidelines recognize (18)F-FDG-PET for seminoma staging.
Purpose of the Study:
- To evaluate the current role and future potential of PET tracers in diagnosing urological malignancies.
- To highlight the limitations and successes of different PET tracers in specific urological cancers.
Main Methods:
- Review of current literature and clinical guidelines on PET imaging in urological cancers.
- Analysis of the diagnostic utility of (18)F-FDG, choline-based tracers, and prostate-specific membrane antigen (PSMA)-targeting tracers.
Main Results:
- PET is not routinely used for renal malignancies due to a lack of specific tracers.
- (18)F-FDG and choline-based PET offer limited additional diagnostic value in bladder cancer, warranting cautious use.
- New PSMA-targeting tracers, such as (68)Ga-PSMA-PET, are transforming prostate cancer imaging.
Conclusions:
- PET imaging in urological malignancies is highly tracer-dependent.
- (68)Ga-PSMA-PET represents a significant advancement and may become standard for prostate cancer work-up.
- Further research into specific tracers is needed for renal and bladder cancers.
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