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Updated: Apr 8, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Developing Peripheral Blood Gene Expression-Based Diagnostic Tests for Coronary Artery Disease: a Review
Brian Rhees1, James A Wingrove
1CardioDx, Inc., 600 Saginaw Dr., Redwood City, CA, 94063, USA, brhees@cardiodx.com.
Abstract:
The past 20 years has witnessed the development of technologies designed to measure changes in the expressed human genome, including the levels of RNA transcripts, proteins, and metabolites. Gene expression profiling, or the measurement of RNA transcripts, allows investigators to obtain a snapshot of a subject's current physiological state and may be used to assess disease likelihood. In this review, we provide an overview of recent work using peripheral blood gene expression to assess coronary artery disease (CAD) and discuss the best approaches for developing and validating tests utilizing such gene expression signatures.
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