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45S5 Bioglass(®)-MWCNT composite: processing and bioactivity.

Harshit Porwal¹, Mehdi Estili, Alina Grünewald

¹School of Engineering and Material Science, Queen Mary University of London, London, E1 4NS, UK.

Journal of Materials Science. Materials in Medicine

|June 26, 2015

Summary

This study fabricated a novel multi-walled carbon nanotube (MWCNT)-Bioglass (BG) composite. While MWCNT addition significantly enhanced electrical conductivity, it inhibited osteoblast-like cell proliferation and viability.

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Area of Science:

Materials Science and Engineering
Biomaterials Science
Nanotechnology

Background:

Bioglass (BG) is a bioactive ceramic with applications in bone regeneration.
Incorporating multi-walled carbon nanotubes (MWCNTs) into BG can enhance its properties, such as electrical conductivity.
Uniform dispersion of MWCNTs in BG matrix is crucial for composite performance and requires advanced fabrication techniques.

Purpose of the Study:

To fabricate a surfactant-free MWCNT-BG composite using aqueous colloidal processing and spark plasma sintering (SPS).
To investigate the effect of MWCNT incorporation on the electrical conductivity of BG.
To conduct a preliminary evaluation of the biological response of osteoblast-like cells on the MWCNT-BG composite.

Main Methods:

Fabrication of MWCNT-BG composite via aqueous colloidal processing without surfactants.
Consolidation of the composite using spark plasma sintering (SPS) to preserve MWCNT integrity.
Characterization of electrical conductivity and preliminary in vitro assessment using MG-63 cells (osteoblast-like).

Main Results:

Achieved uniform dispersion of MWCNTs within the BG matrix, preventing re-agglomeration.
Electrical conductivity of BG increased by 8 orders of magnitude with 6.35 wt% MWCNT addition.
MG-63 cell proliferation, viability, and phenotype expression were inhibited on the 45S5 Bioglass(®)-MWCNT composite surfaces.

Conclusions:

A facile and scalable method for producing well-dispersed MWCNT-BG composites was developed.
MWCNT incorporation dramatically enhances the electrical conductivity of Bioglass.
The fabricated MWCNT-BG composite shows potential for electrically conductive applications but requires further investigation regarding its cytocompatibility.