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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Apr 8, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

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Published on: January 10, 2018

Restoring nervous system structure and function using tissue engineered living scaffolds.

Laura A Struzyna¹, James P Harris¹, Kritika S Katiyar²

¹Center for Brain Injury and Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA ; Center for Neurotrauma, Neurodegeneration, and Restoration, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA.

Neural Regeneration Research

|June 26, 2015

Summary

This summary is machine-generated.

Neural tissue engineering uses living scaffolds to bridge gaps in damaged nervous systems. These engineered tissues promote axonal regeneration, offering a promising strategy for functional recovery after injury or disease.

Keywords:

axon pathfinding biomaterials cell migration cell transplant living scaffolds neural tissue engineering neurodegeneration neurotrauma regeneration

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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Area of Science:

Neuroscience
Biomedical Engineering
Regenerative Medicine

Background:

Disconnection of axon pathways is a hallmark of neurological disorders and injuries.
Functional axonal regeneration is limited by long distances, lack of guidance, and inhibitory factors in the central nervous system.
This results in significant cognitive and sensorimotor deficits.

Purpose of the Study:

To develop and utilize tissue-engineered living scaffolds for nervous system repair.
To restore function by promoting targeted axonal regeneration or replacing neural circuitry.
To facilitate long-distance axonal regeneration and neurosurgical reconstruction.

Main Methods:

Employing preformed three-dimensional constructs of living neural cells with defined architecture.
Utilizing living scaffolds as regenerative bridges to span gaps in neural pathways.
Designing scaffolds to mimic developmental guidance mechanisms for axonal growth.

Main Results:

Living scaffolds serve as pathways for targeted axonal regeneration.
These constructs facilitate long-distance axonal regeneration.
They are being used for neurosurgical reconstruction of local brain circuits.

Conclusions:

Tissue-engineered living scaffolds show promise for nervous system repair.
These constructs can facilitate functional recovery after neurological injury or disease.
Further preclinical and clinical advancements are necessary but promising.