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Plasmids and serogroups in Campylobacter jejuni.

L Lind1, E Sjögren, C Welinder-Olsson

  • 1Department of Clinical Bacteriology, University of Göteborg, Sweden.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|December 1, 1989
PubMed
Summary

Plasmid analysis in Campylobacter strains can complement traditional surface antigen typing for epidemiological studies. This method helps identify bacterial strains, offering a new tool for tracking infections.

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Area of Science:

  • Microbiology
  • Epidemiology
  • Molecular Biology

Background:

  • Campylobacter strain identification for epidemiology traditionally relies on heat-stable (HS) and heat-labile (HL) surface antigen systems.
  • Previous research indicated significant variability within these HS and HL antigen systems.

Purpose of the Study:

  • To investigate the frequency of plasmids in Campylobacter strains.
  • To assess the utility of plasmid profiling as an epidemiological tool.
  • To determine the relationship between plasmid presence/size and HS/HL surface antigens.

Main Methods:

  • Analysis of 242 Campylobacter strains isolated from patients with diarrhea.
  • Plasmid DNA extraction and characterization.
  • Serotyping based on HS and HL antigens.

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Main Results:

  • Plasmids were detected in 70 (28.9%) of the analyzed strains, typically one or two plasmids per strain.
  • The majority of plasmids were in the 21-40 Md molecular weight range.
  • No correlation was found between the presence or size of plasmids and the serogroup of the Campylobacter strains.

Conclusions:

  • Plasmid determination is a viable complementary method to serotyping for Campylobacter epidemiological investigations.
  • Plasmid analysis offers an additional layer of discrimination for strain identification in outbreak investigations.