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Experience of influenza A H1N1 in a paediatric emergency unit
Suat Biçer1, Hülya Ercan Sariçoban1, Ahmet Oğuzhan Özen1
1Department of Child Health and Pediatrics, Faculty of Medicine, Yeditepe University; Department of Medical Microbiology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Insights
Influenza A (H1N1) infection in 2009 was associated with higher fever and myalgia. Patients with H1N1 also showed significantly lower lymphocyte counts compared to those without the virus.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- Influenza A (H1N1) emerged as a significant public health concern during the 2009 influenza season.
- Understanding the clinical spectrum and diagnostic markers of H1N1 is crucial for effective patient management.
Purpose of the Study:
- To evaluate the symptoms, clinical findings, treatment, and complications of H1N1 influenza in emergency unit patients.
- To compare clinical and laboratory findings between patients with and without H1N1 infection.
Main Methods:
- Retrospective evaluation of clinical and laboratory findings of pediatric patients during the 2009 influenza season.
- Diagnosis confirmed by polymerase chain reaction and/or rapid antigen testing.
- Comparison of H1N1-positive (Group I) and H1N1-negative (Group II) patient cohorts.
Main Results:
- H1N1 patients (Group I) exhibited higher fever (mean 39.0°C) and a higher incidence of myalgia compared to Group II.
- Lymphopenia was significantly more prevalent in Group I (81.8%) than in Group II (23.5%).
- Diarrhea was observed in two H1N1 patients without significant respiratory symptoms.
Conclusions:
- Fever and myalgia are key indicators differentiating H1N1 influenza.
- Lymphopenia serves as a significant laboratory marker for H1N1 infection.
- While most cases were managed outpatient, some required hospitalization and oseltamivir treatment.
Abstract:
This study was carried out to evaluate symptoms, clinical findings, treatment options and complications of H1N1 influenza infection in patients who applied to our emergency unit during the influenza season in 2009. The clinical and laboratory findings of children with influenza A (H1N1) during the influenza season in 2009 were evaluated retrospectively. Influenza A was diagnosed by polymerase chain reaction and/or rapid antigen test. Clinical and laboratory findings of the patients with H1N1 (group I) and without H1N1 (group II) were compared. Fever and myalgia were noted to be higher in group I (p <0.05). The mean body temperature in group I was 39.0?, which was statistically different from group II (p <0.001). Myalgia was observed only in group I (15.4%), but not in group II (p <0.05). There were three patients with diarrhoea, two of whom were in group I, and they had no significant respiratory symptoms. Lymphopenia was seen in 18 patients (81.8%) in group I and in four patients (23.5%) in group II (p <0.05). Oseltamivir treatment was applied to 28 patients, where 24 had severe symptoms, nine had comorbid factors and two did not have any of these. The fever was higher in group I and myalgia was present only in group I. In group I, the lymphocyte count was significantly lower than in group II. The fever was higher in patients of H1N1 (average of 39°C) and myalgia was present only in patients with H1N1. The lymphocyte count was significantly lower in patients with H1N1 than those without H1N1. While none of the patients required intensive care, three patients requiring hospitalization were discharged after referral and completion of their treatment.
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