Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

9.8K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-stage repair of contaminated hernias using a novel antibiotic-impregnated biologic porcine submucosa tissue matrix.

BMC surgery·2020
Same author

Characterization of the local wound environment following treatment of chronic leg ulcers with SIS wound matrix.

Journal of tissue viability·2019
Same author

The bolster technique utilising small intestinal submucosa wound matrix: A novel approach to wound treatment.

International wound journal·2019
Same author

An extracellular matrix graft (Oasis<sup>®</sup> wound matrix) for treating full-thickness pressure ulcers: A randomized clinical trial.

Journal of tissue viability·2018
Same author

Nipple Reconstruction with the Biodesign Nipple Reconstruction Cylinder: A Prospective Clinical Study.

Plastic and reconstructive surgery. Global open·2016
Same author

Biologic collagen cylinder with skate flap technique for nipple reconstruction.

Plastic surgery international·2014

Related Experiment Video

Updated: Apr 8, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

22.1K

Small Intestinal Submucosa Wound Matrix for Chronic Wound Healing.

Jason P Hodde, Reynald Allam

    Wounds : a Compendium of Clinical Research and Practice
    |June 26, 2015
    PubMed
    Summary

    Small Intestinal Submucosa Wound Matrix (SISWM) effectively treats chronic wounds by replacing the extracellular matrix (ECM). This advanced wound care stimulates tissue regeneration and promotes healing, improving patient outcomes.

    Area of Science:

    • Regenerative Medicine
    • Biomaterials Science
    • Wound Healing Research

    Background:

    • Chronic wounds, including venous, diabetic, and pressure ulcers, often resist conventional healing.
    • Previous treatments using isolated molecules like collagen and growth factors have shown limited success.
    • The extracellular matrix (ECM) plays a critical role in wound repair, but its failure contributes to chronicity.

    Purpose of the Study:

    • To introduce Small Intestinal Submucosa Wound Matrix (SISWM) as a novel therapeutic approach for chronic wounds.
    • To evaluate SISWM's efficacy in replacing and supporting the native ECM in non-healing wounds.
    • To assess the potential of SISWM to restart and accelerate the wound healing process.

    Main Methods:

    • Utilized Small Intestinal Submucosa Wound Matrix (SISWM), an intact and biologically complex ECM.

    More Related Videos

    Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
    09:06

    Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

    Published on: March 25, 2020

    10.1K
    Murine Model of Wound Healing
    05:39

    Murine Model of Wound Healing

    Published on: May 28, 2013

    68.4K

    Related Experiment Videos

    Last Updated: Apr 8, 2026

    Protocol to Create Chronic Wounds in Diabetic Mice
    06:55

    Protocol to Create Chronic Wounds in Diabetic Mice

    Published on: September 25, 2019

    22.1K
    Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
    09:06

    Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

    Published on: March 25, 2020

    10.1K
    Murine Model of Wound Healing
    05:39

    Murine Model of Wound Healing

    Published on: May 28, 2013

    68.4K
  • Applied SISWM as a "drop-in" replacement for the damaged ECM in chronic wound models.
  • Monitored key healing indicators such as tissue ingrowth, new matrix deposition, and epithelialization.

    • Main Results:

    • SISWM demonstrated effectiveness in promoting tissue ingrowth into the matrix.
    • Significant deposition of new extracellular matrix was observed in treated wounds.
    • Rapid epithelialization was achieved, indicating accelerated wound closure.
    • SISWM acts as a scaffold, supporting cellular infiltration and proliferation.

    Conclusions:

    • Small Intestinal Submucosa Wound Matrix (SISWM) is a viable and effective therapy for managing chronic wounds.
    • SISWM facilitates the regeneration of wound tissue by providing a suitable ECM.
    • This approach offers a promising strategy to improve healing outcomes and enhance patients' quality of life.