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Epigenetic modulation with histone deacetylase inhibitors in combination with immunotherapy

Jeenah Park1, Scott Thomas1, Pamela N Munster1

  • 1Department of Medicine, Hematology/Oncology Division, University of California, San Francisco, CA 94115, USA.

Epigenomics
|June 26, 2015
PubMed

Insights

Histone deacetylase (HDAC) inhibitors, epigenetic modulators, show promise in cancer therapy by reversing resistance and modulating the immune system. Their integration into immunotherapy approaches like vaccines and checkpoint inhibitors is under active clinical investigation.

Area of Science:

  • Oncology
  • Immunology
  • Epigenetics

Background:

  • Dysregulated gene silencing contributes to epigenomic alterations driving cancer development.
  • Histone deacetylase (HDAC) inhibitors are epigenetic modulators with approved uses in T-cell lymphomas and potential in other cancers.
  • HDAC inhibitors exhibit immune-modulatory effects, sparking interest in their role within immunotherapy.

Purpose of the Study:

  • To review the current understanding of integrating HDAC inhibitors into various immunotherapeutic strategies.
  • To summarize ongoing clinical trials exploring epigenetic immune priming.

Main Methods:

  • Literature review of HDAC inhibitors in cancer therapy and immunotherapy.
  • Analysis of clinical trial data on epigenetic immune priming.

Main Results:

  • HDAC inhibitors demonstrate efficacy in reversing therapy resistance.
  • Their immune-modulatory properties suggest potential synergy with immunotherapy.
  • Clinical trials are evaluating novel strategies for epigenetic immune priming.

Conclusions:

  • HDAC inhibitors represent a promising therapeutic strategy, particularly when combined with immunotherapy.
  • Further clinical investigation is warranted to optimize their use in cancer treatment and enhance immune responses.
Keywords:
HDAC inhibitorsadoptive T-cell transfercancerepigeneticsimmune checkpoint inhibitorsimmune responseimmunotherapyvaccines

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