Double trouble in human aneuploidy
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Updated: Apr 8, 2026

Manipulation of Ploidy in Caenorhabditis elegans
Published on: March 15, 2018
Miguel A Brieño-Enríquez1, Paula E Cohen1
1Department of Biomedical Sciences and the Center for Reproductive Genomics, Cornell University, Ithaca, New York, USA.
Abstract:
Crossing over, or reciprocal recombination, is essential for accurate segregation of homologous chromosomes at the first meiotic division, resulting in gametes containing the correct chromosome number. A new study in human oocytes analyzes the genome-wide recombination and segregation patterns in all the products of female meiosis, providing experimental support for existing theories about the origin of human aneuploidies and highlighting a novel reverse segregation mechanism of chromosome segregation during meiosis.
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