[The "block" approach in x-ray diffusion dispersion as a method of studying the packing of secondary structure...

To calculate large angle scattering intensity of biopolymers in solution a "block" method of modeling the globular proteins structures is suggested: conformation of protein alpha-helical and beta-structural parts are described in detail, whereas the remaining part of the macromolecule is substituted by a continuum with homogeneous electron density. A comparison of large-angle scattering curves on the basis of the "block" method and the exact structure was made for a number of alpha-helical and beta-structural globular proteins. It is shown that there is a qualitative agreement between the "exact" and model curves.