Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The dose dependence of various loads using the rosette formation method].

T B Gladysheva, A A Konradov, K A Lebedev

    Biofizika
    |September 1, 1989
    PubMed
    Summary

    T-activin and levamisole significantly enhance lymphocyte and neutrophil functions at very low concentrations (10(-10)-10(-13) g/l). This study explores the impact of these immunomodulators on immune cell activity in vitro.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Combination of two signals of danger--a principal cause of activation of chronic inflammatory processes].

    Fiziologiia cheloveka·2012
    Same author

    [The center of pathological (toxic) action of metals in an people organisms and a role of galvanic currents in its induction].

    Fiziologiia cheloveka·2011
    Same author

    [Molecular and cellular consequences of the Chernobyl accident].

    Radiatsionnaia biologiia, radioecologiia·2011
    Same author

    [Homeostasis of adult stem cells and carcinogenesis].

    Fiziologiia cheloveka·2011
    Same author

    [Immunophysiological mechanism of origin and maintenance of tumor growth in humans].

    Fiziologiia cheloveka·2010
    Same author

    [Infringement of the seasonal rhythm of fluctuations of the oxidized and methylated guanine's contents in urine of mice after the irradiation].

    Radiatsionnaia biologiia, radioecologiia·2010

    Area of Science:

    • Immunology
    • Pharmacology

    Context:

    • Investigating the effects of immunomodulatory drugs on immune cell functions.
    • Utilizing in vitro models to assess cellular responses to specific compounds.

    Purpose:

    • To determine the optimal concentration range of T-activin and levamisole for stimulating immune cell activity.
    • To evaluate the impact of T-activin and levamisole on lymphocyte rosette-formation and neutrophil phagocytosis.

    Summary:

    • Loading tests in rosette-formation were employed to analyze lymphocyte and neutrophil responses.
    • Significant cellular effects were observed with T-activin and levamisole concentrations ranging from 10(-10) to 10(-13) g/l.
    • Leukocytes were preincubated in vitro with varying concentrations of these medications.

    Related Experiment Videos

    Impact:

    • Identifies a narrow, highly effective concentration window for T-activin and levamisole.
    • Provides crucial data for the development and application of these immunomodulatory agents.
    • Highlights the potent biological activity of T-activin and levamisole at the molecular level.