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Profile of urinary tract infections in paediatric patients

Palak Gupta, Jharna Mandal1, Sriram Krishnamurthy

  • 1Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)), Puducherry, India.

The Indian Journal of Medical Research
|June 27, 2015
PubMed

Insights

This study on pediatric urinary tract infections (UTI) found that age and gender influence UTI profiles and outcomes. Boys over one year with UTI require extensive evaluation due to higher risks of vesicoureteric reflux (VUR) and renal scarring.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Urology

Background:

  • Urinary tract infections (UTI) are common in children, with varying presentations and potential for long-term sequelae.
  • Understanding the specific profile of pediatric UTI, including causative pathogens and associated anatomical abnormalities, is crucial for effective management.

Purpose of the Study:

  • To determine the epidemiological profile of pediatric UTI.
  • To identify common bacterial pathogens and their antibiotic susceptibility patterns.
  • To assess the prevalence of vesicoureteric reflux (VUR) and renal scarring in children with UTI.

Main Methods:

  • A cross-sectional study included 524 children under 13 years with suspected UTI.
  • Uropathogen isolation and antibiotic susceptibility testing were performed.
  • Micturating cysto-urethrography (MCU) and DMSA scans were utilized to evaluate VUR and renal scarring.

Main Results:

  • Culture-proven UTI was diagnosed in 186 (35.4%) children, with a higher incidence in males (69.35%) and infants (56.4%).
  • Vesicoureteric reflux (VUR) was observed in 18 patients and renal scarring in 33.
  • Escherichia coli was the predominant pathogen, showing sensitivity to nitrofurantoin, aminoglycosides, and cefoperazone-sulbactam.

Conclusions:

  • Pediatric UTI prevalence and characteristics vary significantly with age and gender.
  • Boys over one year of age with UTI warrant thorough investigation for VUR and renal scarring.
  • Aminoglycosides, cefoperazone-sulbactam, and nitrofurantoin demonstrated superior in vitro efficacy against Gram-negative uropathogens compared to meropenem.
Abstract

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