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Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
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Depression: Overview01:18

Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Related Experiment Video

Updated: Apr 8, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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A Two-Phase Pathogenetic Model of Depression after Stroke.

Katja Werheid1

  • 1Department of Psychology, Humboldt Universität zu Berlin, Berlin, Germany.

Gerontology
|June 27, 2015
PubMed
Summary

Poststroke depression (PSD) affects 30% of stroke survivors, impacting recovery and quality of life. A new biphasic model integrates risk factors to better understand and manage PSD emergence within two years post-stroke.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Medicine

Background:

  • Poststroke depression (PSD) is a common complication affecting approximately 30% of stroke survivors.
  • PSD is linked to poorer recovery, reduced quality of life, and increased mortality.
  • Existing knowledge on organic and psychosocial risk factors for PSD is substantial, yet their interaction remains unclear.

Purpose of the Study:

  • To review and discuss existing pathogenetic models of PSD.
  • To propose a new biphasic model for PSD emergence.
  • To integrate premorbid, stroke-related, and psychosocial risk factors within the first two years after stroke.

Main Methods:

  • Review of pathogenetic PSD models from the 1980s and 1990s.
  • Analysis of longitudinal research published on PSD.

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  • Development of a biphasic model integrating various risk factors.

    • Main Results:

    • A novel biphasic model for PSD emergence is proposed.
    • The model integrates premorbid, stroke-related, and psychosocial risk factors.
    • The distinction between 'reactive' and 'organic' PSD is no longer supported.

    Conclusions:

    • The proposed biphasic model offers a comprehensive framework for understanding PSD.
    • Identified risk factor groups are recommended for future research.
    • The model has potential implications for PSD prevention and therapeutic strategies.