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Monitoring accumulating data in a clinical trial
1School of Statistics, University of Minnesota, Minneapolis 55455.
Biometrics
|December 1, 1989
Abstract:
A clinical trial is monitored for efficacy or safety; the variable of interest is death or a similarly serious event. The probability that one therapy has a greater mortality rate than the other is calculated ad libitum during the trial. Adjustments are made for differing patients' prognoses and for survival times.