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Updated: Aug 17, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
[Immunobiological activity of platinum coordination compounds in a complex with immunoglobulin fragments]
Abstract:
The investigation of biological activity of two coordination platinum (II) compounds covalently linked with Fab-fragments of nonspecific immunoglobulin donors on mononuclears of peripheral man blood in vitro and blood elements of mice BALB/c has been done in this paper. There have been stated the decrease of cytotoxic activity of platinum reagents after complexing and modulating influence of platinum-globulin complexes on immunocompetent cells. The prospects of increasing biological activity of immunological preparations on the basis of directed modification by platinum reagents has been also discussed.
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