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Updated: Apr 8, 2026
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
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Coagulation Parameters in Wilson Disease
Mark Schaefer1, Laura Weber1, Daniel Gotthardt1
1Department of Gastroenterology and Hepatology, University Hospital Heidelberg, Heidelberg, Germany.
Journal of Gastrointestinal and Liver Diseases : JGLD
|June 27, 2015
Summary
Wilson disease (WD) patients show some altered coagulation factors, particularly with certain treatments. However, these changes are not clinically significant for the overall coagulation system in WD.
Area of Science:
- Hepatology
- Hematology
- Genetics
Background:
- Wilson disease (WD) is an inherited disorder affecting copper metabolism.
- Altered copper metabolism in WD may impact blood coagulation factors.
Purpose of the Study:
- To analyze coagulation factor levels in patients with Wilson disease.
Main Methods:
- A prospective cross-sectional cohort study of 100 WD patients.
- Coagulation factors, including clotting factors, von Willebrand factor, and others, were assessed.
- Subgroup analyses were performed based on sex, clinical presentation, WD treatment, and liver function.
Main Results:
- Decreased levels of factors II, V, VII, and X were observed with impaired liver function.
- Trientine treatment was associated with decreased factors II, VII, antithrombin III, and increased von Willebrand factor.
- Zinc treatment correlated with reduced factor VIII levels.
Conclusions:
- While some coagulation parameters differ in subgroups, no clinically relevant alterations in the coagulation system were found in WD patients.
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