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Coagulation Parameters in Wilson Disease.

Mark Schaefer1, Laura Weber1, Daniel Gotthardt1

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Summary
This summary is machine-generated.

Wilson disease (WD) patients show some altered coagulation factors, particularly with certain treatments. However, these changes are not clinically significant for the overall coagulation system in WD.

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Area of Science:

  • Hepatology
  • Hematology
  • Genetics

Background:

  • Wilson disease (WD) is an inherited disorder affecting copper metabolism.
  • Altered copper metabolism in WD may impact blood coagulation factors.

Purpose of the Study:

  • To analyze coagulation factor levels in patients with Wilson disease.

Main Methods:

  • A prospective cross-sectional cohort study of 100 WD patients.
  • Coagulation factors, including clotting factors, von Willebrand factor, and others, were assessed.
  • Subgroup analyses were performed based on sex, clinical presentation, WD treatment, and liver function.

Main Results:

  • Decreased levels of factors II, V, VII, and X were observed with impaired liver function.
  • Trientine treatment was associated with decreased factors II, VII, antithrombin III, and increased von Willebrand factor.
  • Zinc treatment correlated with reduced factor VIII levels.

Conclusions:

  • While some coagulation parameters differ in subgroups, no clinically relevant alterations in the coagulation system were found in WD patients.