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Updated: Apr 8, 2026

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
Published on: July 21, 2023
Out-of-Plane Plasmonic Antennas for Raman Analysis in Living Cells
Rosanna La Rocca1, Gabriele C Messina1, Michele Dipalo1
1Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
Abstract:
Out-of-plane plasmonic nanoantennas protruding from the substrate are exploited to perform very sensitive surface enhanced Raman scattering analysis of living cells. Cells cultured on three-dimensional surfaces exhibit tight adhesion with nanoantenna tips where the plasmonic hot-spot resides. This fact provides observable cell adhesion sites combined with high plasmonic enhancement, resulting in an ideal system for Raman investigation of cell membranes.
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