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Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
Published on: April 25, 2025
[77-year-old female with hyponatremia, pruritus and papulous exanthema]
Judith Brock1, Thomas Karrasch1, Fritz Christian Roller
1Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen.
History And Clinical Findings:
A 77 year old female patient was admitted for the evaluation of hyponatremia and a generalized papulous exanthema with severe pruritus.
Investigations And Diagnosis:
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) could be diagnosed as cause for hyponatremia. Biopsy of a soft tissue tumor revealed a T-cell lymphoma with widespread skelettal dissemination.
Treatment And Course:
Chemotherapy caused a rapid response and improvement of general well-being. SIADH could be controlled by the specific vasopressin-2-receptor antagonist tolvaptan.
Conclusions:
In this patient, both the papulous exanthema and the SIADH are regarded as T-cell-lymphoma-associated paraneoplastic syndromes.
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Disorder of Water Balance
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
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The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
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