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Thalamic resting-state functional connectivity: disruption in patients with type 2 diabetes
Yu-Chen Chen1, Wenqing Xia, Cheng Qian
1Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87# Dingjiaqiao Road, Nanjing, 210009, China.
Type 2 diabetes mellitus (T2DM) disrupts thalamic functional connectivity, impacting cognitive functions like verbal fluency and executive function. These brain connectivity changes are linked to cognitive deficits in T2DM patients.
Area of Science:
- Neuroimaging
- Endocrinology
- Cognitive Neuroscience
Background:
- Type 2 diabetes mellitus (T2DM) is increasingly associated with cognitive dysfunction.
- The role of thalamic functional connectivity in T2DM-related cognitive impairment remains underexplored.
Purpose of the Study:
- To investigate alterations in thalamic functional connectivity in T2DM patients.
- To examine the relationship between disrupted thalamic connectivity and cognitive deficits in T2DM.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) and T1-weighted imaging were used.
- Seed-based correlation analysis characterized thalamic functional connectivity.
- Pearson correlation assessed associations between connectivity and cognitive test scores.
Main Results:
- T2DM patients exhibited decreased thalamic connectivity in regions including the right middle temporal gyrus and bilateral occipital cortex.
- Increased connectivity was observed in the left cerebellum and bilateral middle frontal gyrus.
- Decreased connectivity in specific regions correlated with poorer performance on verbal fluency, complex figure, and trail making tests.
Conclusions:
- T2DM is associated with disrupted thalamocortical functional connectivity.
- These connectivity disturbances are linked to specific cognitive impairments in T2DM.
- Resting-state thalamocortical connectivity alterations may underlie T2DM-related cognitive dysfunction.
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