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Related Experiment Videos

Seizures decrease regional enzymatic hydrolysis of N-acetyl-aspartylglutamate in rat brain.

J L Meyerhoff1, M B Robinson, M A Bixler

  • 1Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307.

Brain Research
|December 25, 1989
PubMed
Summary
This summary is machine-generated.

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Kindled seizures decrease N-acetylated-alpha-linked acidic dipeptidase (NAALADase) activity, reducing N-acetyl-aspartylglutamate (NAAG) hydrolysis. This may be a protective mechanism against further seizures by limiting glutamate availability.

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Biochemistry

Background:

  • Kindled seizures elevate N-acetyl-aspartylglutamate (NAAG) in the entorhinal cortex.
  • Non-kindled convulsions do not affect NAAG levels.
  • NAAG is hydrolyzed by N-acetylated-alpha-linked acidic dipeptidase (NAALADase) into glutamate (Glu) and N-acetyl-aspartate (NAA).

Purpose of the Study:

  • To investigate the effect of amygdaloid kindling on NAALADase activity in brain regions implicated in limbic seizures.
  • To explore the relationship between epilepsy and NAAG metabolism.

Main Methods:

  • Amygdaloid kindling was used to induce seizures in animal models.
  • NAALADase activity was measured in various brain regions.
  • Effects of kindling and non-kindled convulsions were compared.

Related Experiment Videos

Main Results:

  • Convulsions significantly decreased NAALADase activity across multiple brain regions.
  • Hippocampal NAALADase decrease was specific to kindling.
  • Larger decreases in other limbic regions were non-specific aftereffects of convulsions.

Conclusions:

  • Reduced NAALADase activity following seizures may limit synaptic glutamate availability.
  • This reduction could represent a homeostatic mechanism to decrease seizure susceptibility.
  • Findings suggest a role for NAAG metabolism in epilepsy pathophysiology.