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Updated: Apr 8, 2026
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Published on: February 12, 2018
Regenerative Approach to Scleroderma with Fat Grafting
Guy Magalon1, Aurélie Daumas2, Nolwenn Sautereau2
1Plastic Surgery Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France; Culture and Cell Therapy Laboratory, INSERM CBT-1409, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France.
Fat grafting offers an autologous filler option, with adipose-derived stem cells showing promise for treating systemic sclerosis. This innovative therapy targets skin fibrosis and microvascular damage in affected patients.
Area of Science:
- Regenerative Medicine
- Immunology
- Dermatology
Background:
- Autologous fat grafting is a well-established procedure with ideal filler characteristics.
- Adipose-tissue-derived stromal vascular fraction (SVF) is rich in stem cells, endothelial progenitors, and immune cells.
- Systemic sclerosis is a rare autoimmune disease causing skin fibrosis and microvascular damage.
Purpose of the Study:
- To evaluate the potential of fat grafting and SVF therapy for systemic sclerosis.
- To present an innovative therapeutic approach for facial and hand manifestations of systemic sclerosis.
Main Methods:
- Utilizing lipoaspirate to isolate adipose-tissue-derived stromal vascular fraction.
- Applying fat grafting to the face and SVF to the hands of patients with systemic sclerosis.
Main Results:
- Fat grafting provides an autologous, integrated filler with regenerative potential.
- SVF offers a source of reparative cells for tissue regeneration.
- The combined approach shows promise for treating systemic sclerosis symptoms.
Conclusions:
- Fat grafting and SVF represent a promising, innovative therapy for systemic sclerosis.
- This approach addresses key pathological features like fibrosis and microvascular damage.
- Further research is warranted to establish efficacy and long-term outcomes.
