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Related Experiment Videos

PVN steroid implants: effect on feeding patterns and macronutrient selection.

D L Tempel1, S F Leibowitz

  • 1Rockefeller University, New York, NY 10021.

Brain Research Bulletin
|December 1, 1989
PubMed
Summary
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Corticosterone (CORT) and aldosterone (ALDO) implants in the brain

Area of Science:

  • Neuroendocrinology
  • Behavioral Neuroscience
  • Metabolic Regulation

Background:

  • Glucocorticoids like corticosterone (CORT) significantly influence feeding behavior, body weight, and metabolism.
  • The hypothalamic paraventricular nucleus (PVN) contains alpha 2-noradrenergic feeding systems and distinct glucocorticoid receptor subtypes.
  • Previous research suggests an interaction between circulating CORT and the PVN's feeding system.

Purpose of the Study:

  • To investigate the functional roles of specific glucocorticoid receptors within the PVN.
  • To determine how direct PVN implantation of CORT and other steroid hormones affects feeding patterns and macronutrient selection.

Main Methods:

  • Steroid hormones, including crystalline CORT and aldosterone (ALDO), were implanted directly into the PVN of rats.

Related Experiment Videos

  • Rats were adrenalectomized (ADX) or sham-operated to control for endogenous hormone levels.
  • Feeding patterns and macronutrient selection were monitored during the nocturnal feeding cycle.

    • Main Results:

    • PVN CORT implants stimulated carbohydrate intake in ADX rats, particularly at the onset of the dark cycle.
    • Aldosterone (ALDO) implants stimulated fat intake in both sham and ADX rats throughout the dark cycle.
    • ALDO also enhanced carbohydrate intake in ADX rats at dark onset, while dexamethasone showed a minor carbohydrate stimulatory effect.

    Conclusions:

    • Adrenal hormones act centrally to modulate nutrient intake.
    • The distinct effects of CORT and ALDO suggest differential mediation by Type 1 and Type 2 steroid receptor subtypes in the brain.
    • These findings highlight specific roles for PVN steroid receptors in regulating feeding behavior and macronutrient selection.