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In vitro dissolution-permeation evaluation of an electrospun cyclodextrin-based formulation of aripiprazole using
Enikő Borbás1, Attila Balogh1, Katalin Bocz1
1Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Hungary.
International Journal of Pharmaceutics
|June 29, 2015
Summary
Newly developed electrospun cyclodextrin formulations enhance dissolution and permeation of poorly water-soluble drugs like aripiprazole. This novel approach improves drug delivery across biological membranes for better therapeutic outcomes.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Increasing number of poorly water-soluble active pharmaceutical ingredients (APIs) presents a significant challenge in drug development.
- Traditional formulation methods primarily focus on dissolution enhancement, often neglecting the impact on drug permeation across biological membranes.
- Optimizing both dissolution and permeation is crucial for effective drug delivery and improved in vitro-in vivo correlation.
Purpose of the Study:
- To evaluate an electrospun cyclodextrin-based formulation of aripiprazole for enhanced dissolution and permeation.
- To assess the performance of the novel μFlux apparatus for simultaneous monitoring of dissolution and permeation.
- To establish a better in vitro-in vivo correlation for poorly water-soluble drugs.
Main Methods:
- Utilizing an electrospun cyclodextrin-based formulation of aripiprazole.
- Employing the novel μFlux apparatus for simultaneous in vitro dissolution and permeation testing.
- Analyzing drug flux across biological membranes in conjunction with dissolution profiles.
Main Results:
- The cyclodextrin-based electrospun formulation demonstrated ultrafast dissolution of aripiprazole.
- Enhanced drug flux across membranes was observed, indicating improved permeation.
- The μFlux apparatus facilitated a comprehensive assessment of drug release and transport.
Conclusions:
- Electrospun cyclodextrin formulations show significant potential for rapid drug delivery, particularly through oral mucosa.
- The combination of ultrafast dissolution and enhanced membrane permeation is key to this formulation's efficacy.
- The μFlux apparatus provides a valuable tool for achieving better in vitro-in vivo correlation in drug development.
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