Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.3K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.3K
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

2.1K
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
2.1K
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

2.1K
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
2.1K
Epistasis Analysis01:09

Epistasis Analysis

6.2K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
6.2K
Genomics02:02

Genomics

41.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.8K
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.9K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Graphic Depictions: Portrayals of Mental Illness in Video Games.

Journal of forensic sciences·2016
Same author

Menopausal hormone therapy and lung cancer: Now you see it, now you don't.

Maturitas·2016
Same author

Persistent denial of undeniable bias.

Climacteric : the journal of the International Menopause Society·2015
Same author

Risk of breast cancer during hormone replacement therapy: mechanisms.

Hormone molecular biology and clinical investigation·2015
Same author

Misrepresentation of the risk of ovarian cancer among women using menopausal hormones. Spurious findings in a meta-analysis.

Maturitas·2015
Same author

Whether the use of unopposed oestrogen following a myocardial infarction is beneficial or harmful remains unclear, and in individual women the effects may vary according to the underlying risk profile.

Evidence-based medicine·2014

Related Experiment Video

Updated: Apr 8, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

2.0K

Commentary. Oligognostic mega-analysis. Is Archie turning in his grave?

Samuel Shapiro1

  • 1Department of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town Medical School, Cape Town, South Africa.

Maturitas
|June 29, 2015
PubMed
Summary
This summary is machine-generated.

Meta-analysis is informative for short trials but problematic for prolonged or observational studies due to bias and methodological issues. Systematic reviews offer an alternative but tailored qualitative reviews are superior.

More Related Videos

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
06:40

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography

Published on: June 15, 2018

10.8K
A Multi-Omics Extraction Method for the In-Depth Analysis of Synchronized Cultures of the Green Alga Chlamydomonas reinhardtii
07:51

A Multi-Omics Extraction Method for the In-Depth Analysis of Synchronized Cultures of the Green Alga Chlamydomonas reinhardtii

Published on: August 8, 2019

8.3K

Related Experiment Videos

Last Updated: Apr 8, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

2.0K
Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
06:40

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography

Published on: June 15, 2018

10.8K
A Multi-Omics Extraction Method for the In-Depth Analysis of Synchronized Cultures of the Green Alga Chlamydomonas reinhardtii
07:51

A Multi-Omics Extraction Method for the In-Depth Analysis of Synchronized Cultures of the Green Alga Chlamydomonas reinhardtii

Published on: August 8, 2019

8.3K

Area of Science:

  • Evidence-based medicine
  • Biostatistics
  • Research methodology

Background:

  • The Cochrane Collaboration provides guidelines for systematic reviews and meta-analyses.
  • Meta-analysis is a statistical technique for combining results of independent studies.
  • Systematic reviews synthesize findings from multiple studies.

Purpose of the Study:

  • To evaluate the validity and limitations of meta-analysis and systematic reviews.
  • To discuss the challenges in applying these methods to different study designs.
  • To compare standardized systematic reviews with qualitative reviews.

Main Methods:

  • Analysis of methodological challenges in meta-analysis of randomized controlled trials (RCTs) and observational studies.
  • Evaluation of systematic review methodologies, including standardized and qualitative approaches.
  • Discussion of factors affecting the reliability of meta-analyses, such as trial duration and data quality.

Main Results:

  • Meta-analysis is reliable for short-duration RCTs but compromised in prolonged trials due to unblinding, non-adherence, and crossovers.
  • Meta-analysis of observational studies is frequently invalid due to bias, confounding, and methodological variability.
  • Standardized systematic reviews are useful for non-quantitative data but are less effective than tailored qualitative reviews.

Conclusions:

  • Meta-analysis has significant limitations, particularly with prolonged or observational studies.
  • Systematic reviews require careful consideration of methodology, with qualitative reviews often being superior for specific topics.
  • The application of meta-analysis and systematic reviews must account for study design and potential biases to ensure valid results.