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Updated: Apr 8, 2026
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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
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Group 2 innate lymphoid cells and asthma.
Hiroki Kabata1, Kazuyo Moro2, Shigeo Koyasu3
1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Internal Medicine, Kawasaki Municipal Hospital, Kanagawa, Japan; Laboratory for Immune Cell Systems, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa, Japan.
Summary
Group 2 innate lymphoid cells (ILC2s) are key players in asthma. These cells drive allergic inflammation and airway hyperresponsiveness in mouse models, with emerging evidence suggesting a similar role in human asthma.
Area of Science:
- Immunology
- Allergy Research
- Respiratory Medicine
Background:
- Group 2 innate lymphoid cells (ILC2s) are newly discovered immune cells.
- ILC2s produce type 2 cytokines like IL-5 and IL-13.
- Initially linked to anti-helminth immunity, ILC2s are now implicated in allergic diseases.
Purpose of the Study:
- To review the role of ILC2s in asthma.
- To compare ILC2 function in mouse models and humans.
- To discuss ILC2 involvement in allergic airway inflammation.
Main Methods:
- Review of existing literature on ILC2s in asthma.
- Analysis of studies in mouse asthma models.
- Examination of human ILC2 studies related to asthma.
Main Results:
- ILC2s induce eosinophilic inflammation and airway hyperresponsiveness in mouse asthma models.
- ILC2s can influence acquired immunity and Th2 polarization.
- Human ILC2s show differences in responsiveness and cytokine production compared to mouse ILC2s.
- Evidence suggests human ILC2s contribute to allergic asthma and exacerbations.
Conclusions:
- ILC2s are significant contributors to asthma pathogenesis.
- Understanding ILC2 function is crucial for developing asthma therapies.
- Further research is needed on human ILC2s in asthma.
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