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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

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Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Updated: Apr 8, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Systemic capillary leak syndrome: a case-report.

Thomas E Manning, Anna E Manning, Patrick J Manning1

  • 1Department of Medicine, Dunedin, New Zealand. patrickmanning@healthotago.co.nz.

The New Zealand Medical Journal
|June 29, 2015
PubMed
Summary

Systemic capillary leak syndrome (SCLS) can cause episodic hypotension, tachycardia, and edema. Oral theophylline effectively managed this patient's SCLS symptoms, preventing further episodes.

Area of Science:

  • Internal Medicine
  • Hematology
  • Immunology

Background:

  • Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by recurrent episodes of hypotension, hemoconcentration, and edema.
  • Diagnosis often relies on clinical presentation and exclusion of other causes.
  • The underlying pathophysiology of SCLS remains incompletely understood.

Observation:

  • A patient presented with recurrent episodes of hypotension, tachycardia, and peripheral edema.
  • Laboratory investigations revealed an elevated serum IgG kappa paraprotein level.
  • The patient was diagnosed with systemic capillary leak syndrome.

Findings:

  • Initiation of oral theophylline therapy resulted in complete resolution of SCLS symptoms.
  • The patient experienced no further episodes of hypotension, tachycardia, or edema after starting theophylline.

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  • The patient later progressed to a diagnosis of multiple myeloma.

    • Implications:

    • Theophylline may represent a novel therapeutic option for managing systemic capillary leak syndrome.
    • This case highlights the potential link between paraproteinemias and SCLS.
    • Further research is warranted to elucidate the mechanism of theophylline's efficacy in SCLS and its potential role in managing related hematologic conditions.