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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

MicroRNAs

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Related Experiment Video

Updated: Apr 8, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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[MicroRNAs and prostate cancer].

Wen-ting Xu, Ying-jie Jia, Xiao-jiang Li

    Zhonghua Nan Ke Xue = National Journal of Andrology
    |June 30, 2015
    PubMed
    Summary

    This study explores how microRNAs (small ribonucleic acid molecules) impact prostate cancer (PCa) development and progression. It details specific microRNAs linked to PCa, affecting prognosis and treatment.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Background:

    • Prostate cancer (PCa) is a prevalent male malignancy.
    • MicroRNAs (non-coding small RNAs) are increasingly recognized for their role in PCa.
    • Aberrant microRNA expression is a hallmark of PCa.

    Purpose of the Study:

    • To elucidate the role of microRNAs in prostate cancer occurrence and progression.
    • To identify differentially expressed microRNAs in PCa.
    • To analyze the association of microRNAs with PCa prognosis, chemotherapy, androgen receptors, and metastasis.

    Main Methods:

    • Literature review and analysis of existing studies on microRNAs in prostate cancer.
    • Identification and cataloging of microRNAs with altered expression in PCa.

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  • Correlation analysis of microRNA expression with clinical parameters and treatment responses.

    • Main Results:

    • Specific microRNAs are demonstrably dysregulated in prostate cancer.
    • These microRNAs correlate with various aspects of PCa, including tumor aggressiveness and patient outcomes.
    • MicroRNA expression patterns are linked to chemotherapy response and metastatic potential.

    Conclusions:

    • MicroRNAs play a significant role in the pathogenesis and progression of prostate cancer.
    • Dysregulated microRNAs represent potential biomarkers for PCa diagnosis and prognosis.
    • Targeting microRNAs may offer novel therapeutic strategies for prostate cancer.