[Fosfomycin for urogenital tract infections: Advances in studies]

Area of Science:

• Pharmacology
• Microbiology
• Infectious Diseases

Background:

• Fosfomycin (FOM) is a broad-spectrum antibiotic characterized by a low molecular weight, long half-life, and unique antibacterial mechanism.
• It functions by inhibiting bacterial cell wall synthesis, offering bactericidal activity.
• FOM exhibits good drug tolerance, compliance, and low potential for inducing bacterial resistance, with no cross-resistance to other antibiotics.

Purpose of the Study:

• To review the clinical applications of Fosfomycin in treating infectious diseases of the urogenital tract.
• To highlight FOM's efficacy in managing conditions such as acute uncomplicated urinary tract infections, prostatitis, and epididymitis.

Main Methods:

• This review synthesizes existing scientific literature on Fosfomycin's clinical use.
• Focus is placed on studies demonstrating its effectiveness in urogenital tract infections.

Main Results:

• Fosfomycin demonstrates effectiveness in treating acute uncomplicated urinary tract infections.
• It is also effective for other urogenital tract infections, including prostatitis and epididymitis.
• The antibiotic is well-tolerated and has a low propensity for resistance development.

Conclusions:

• Fosfomycin is a clinically valuable antibiotic for treating urogenital tract infections.
• Its broad spectrum, favorable safety profile, and low resistance potential support its use in this area.