Related Experiment Video

Updated: Apr 8, 2026

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
11:37

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells

Published on: February 18, 2015

14.3K

Innovative therapy of ovarian cancer based on overexpression of CD44 receptor

Barbara Bukowska, Agnieszka Marczak

    Ginekologia Polska
    |June 30, 2015
    PubMed

    Insights

    Targeting CD44, a protein overexpressed in ovarian cancer, offers a promising strategy for drug delivery. This approach enhances treatment efficiency for ovarian carcinoma, a leading cause of cancer death in women.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Drug Delivery Systems

    Background:

    • Ovarian carcinoma is a leading cause of cancer-related mortality in women, with low curability rates.
    • CD44, a cell-surface glycoprotein binding hyaluronic acid (HA), regulates cell processes and is overexpressed in ovarian cancer.

    Purpose of the Study:

    • To review the current knowledge on CD44-targeting as a novel therapeutic strategy for ovarian cancer.
    • To evaluate the potential of CD44-targeting for selective drug delivery to ovarian cancer cells.

    Main Methods:

    • Literature review summarizing research on CD44 function and overexpression in ovarian cancer.
    • Analysis of CD44-targeting strategies for drug delivery carriers (e.g., paclitaxel, doxorubicin, cisplatin).

    Main Results:

    • Overexpression of CD44 in ovarian cancer cells enables its use as a target for selective drug delivery.
    • CD44-targeting facilitates the development of carriers for delivering various chemotherapeutic agents directly to cancer cells.

    Conclusions:

    • CD44-targeting represents a promising and efficient approach for ovarian cancer treatment.
    • This strategy holds significant therapeutic potential for improving patient outcomes in ovarian carcinoma.

    More Related Videos

    Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-107:59

    Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

    Published on: December 5, 2020

    3.1K
    Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence08:55

    Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

    Published on: November 2, 2014

    12.9K

    Related Concept Videos

    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
    There are several types of targeted therapies against...
    9.1K
    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    1.8K
    Tumor Immunotherapy01:27

    Tumor Immunotherapy

    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
    2.3K
    Treatment Resistant Cancers02:56

    Treatment Resistant Cancers

    Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
    3.9K
    Treatment Resistent Cancers02:56

    Treatment Resistent Cancers

    1.5K
    Cancer Therapies02:49

    Cancer Therapies

    Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
    However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
    10.7K