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Updated: Apr 8, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
[LYMPHOCYTES MEMBRANES FATTY ACID SPECTRUM IN PATIENTS WITH CORONARY HEART DISEASE].
Coronary heart disease patients show altered lymphocyte fatty acids, with decreased oleic acid and increased saturated fatty acids. These changes impact cell membrane structure and function, potentially explaining increased lymphocyte activity.
Area of Science:
- Cardiovascular Science
- Cell Biology
- Lipid Metabolism
Context:
- Investigates the relationship between coronary heart disease (CHD) and cellular lipid profiles.
- Focuses on the specific alterations in lymphocyte phospholipid membranes.
- Examines a cohort of 77 patients aged 45-72 years with diagnosed CHD.
Purpose:
- To analyze the fatty acid spectrum of lymphocyte phospholipid membranes in patients with coronary heart disease.
- To identify specific fatty acid changes associated with CHD.
- To explore the potential functional implications of these lipid alterations.
Summary:
- Significant decrease in oleic acid content observed in lymphocytes of CHD patients, potentially disrupting membrane structure and function.
- Increased relative content of arachidonic, palmitic, and stearic saturated fatty acids found in lymphocyte lipids.
- Evidence suggests increased polyunsaturated fatty acid elongation in lymphocytes of CHD patients, correlating with altered lipid profiles.
Impact:
- Identifies specific lipid alterations in lymphocytes as potential biomarkers for coronary heart disease.
- Provides insights into the mechanisms by which CHD affects cellular membrane integrity and function.
- Suggests a link between observed lipid changes, lymphocyte membrane structure, and functional activity in CHD patients.
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