[SELENIUM EFFICIENCY IN PROPHYLAXIS AND COMPLEX TREATMENT OF DIFFUSE GOITER].

Area of Science:

• Endocrinology
• Nutritional Science

Background:

• Diffuse goiter affects men aged 41-50.
• Diagnosis relies on palpation and ultrasound of the thyroid gland.

Purpose of the Study:

• To investigate the efficacy of combined selenium and iodine prophylaxis and treatment for diffuse goiter.
• To compare combined therapy with iodine monotherapy and dynamic supervision.

Main Methods:

• 54 men aged 41-50 with diffuse goiter (1st-2nd degree) were divided into three groups.
• Group 1: Selenium and iodine preparations for 3 months.
• Group 2: Iodine preparations for 3 months.
• Control group: Dynamic supervision.
• Thyroid volume measured and compared to body surface area.

Main Results:

• Combined selenium and iodine therapy led to a significant reduction in thyroid volume (2.15 cm³/M² ± 0.07 cm³/M²).
• 11.8% of patients in the combined therapy group showed normalization of thyroid volume.
• Iodine monotherapy resulted in a less pronounced reduction (0.92 cm³/M² ± 0.17 cm³/M²).

Conclusions:

• Combined selenium and iodine preparations are recommended for diffuse goiter prophylaxis and treatment.
• Effective in areas with combined selenium and mild iodine deficiency.
• Selenium dosage of 100 mcg/day with iodine is suggested.