Related Experiment Video

Updated: Apr 8, 2026

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
07:34

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide

Published on: May 12, 2023

1.6K

[Farnesoid X receptor regulates glucose and lipid metabolisms]

Qian Jiang, Jun Peng, Shuai-nan Liu

    Yao Xue Xue Bao = Acta Pharmaceutica Sinica
    |June 30, 2015
    PubMed

    Insights

    Farnesoid X receptor (FXR) regulates metabolism, including bile acid, lipid, and glucose homeostasis. Activating FXR shows potential for treating metabolic disorders like type 2 diabetes and dyslipidemia.

    Area of Science:

    • Endocrinology and Metabolism
    • Molecular Biology

    Background:

    • The farnesoid X receptor (FXR) is a nuclear receptor superfamily member.
    • FXR plays a critical role in regulating diverse metabolic pathways.

    Purpose of the Study:

    • To highlight the role of FXR in metabolic regulation.
    • To explore FXR as a potential therapeutic target for metabolic disorders.

    Main Methods:

    • Literature review on FXR's function in metabolic pathways.
    • Analysis of FXR's involvement in bile acid, lipid, and glucose homeostasis.
    • Assessment of current research on FXR activation for therapeutic benefits.

    Main Results:

    • FXR activation is crucial for maintaining bile acid metabolism.
    • FXR significantly contributes to lipid and glucose homeostasis.
    • Prevalence of metabolic disorders increases interest in FXR.

    Conclusions:

    • FXR is a key regulator of metabolic processes.
    • Targeting FXR presents a promising therapeutic strategy for type 2 diabetes mellitus.
    • FXR activation may offer a novel approach for managing lipid disorders.

    More Related Videos

    Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro09:41

    Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

    Published on: March 17, 2023

    4.0K
    Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads07:59

    Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

    Published on: July 21, 2017

    10.2K

    Related Concept Videos

    Transducer Mechanism: Nuclear Receptors01:31

    Transducer Mechanism: Nuclear Receptors

    Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
    About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
    6.0K
    Glucose Homeostasis: Regulation of Blood Glucose01:02

    Glucose Homeostasis: Regulation of Blood Glucose

    Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
    During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
    5.4K
    Hormones Regulating Blood Glucose01:16

    Hormones Regulating Blood Glucose

    Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
    In addition to accelerating glucose uptake and utilization, insulin has...
    8.7K
    Insulin: The Receptor and Signaling Pathways01:28

    Insulin: The Receptor and Signaling Pathways

    Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
    6.2K
    Regulation of Metabolism01:19

    Regulation of Metabolism

    Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
    12.4K
    Cholesterol: Significance and Regulation01:29

    Cholesterol: Significance and Regulation

    Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
    Considering cholesterol and...
    1.9K