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Published on: August 7, 2017
The Platelet Parameters as Inflammatory Markers in Preschool Children with Atopic Eczema
Insights
In preschool children, atopic eczema (AE) is associated with increased mean platelet volume (MPV) and decreased platelet distribution width (PDW) and PLT/MPV ratio, indicating inflammation. AE severity did not correlate with these platelet parameters.
Area of Science:
- Pediatric Dermatology
- Hematology
- Immunology
Background:
- Mean platelet volume (MPV) is a recognized inflammatory marker in various diseases.
- Atopic eczema (AE) is a common inflammatory skin condition in children.
- Platelet parameters may offer insights into the inflammatory processes in AE.
Purpose of the Study:
- To compare platelet parameter levels between preschool children with and without atopic eczema (AE).
- To investigate the relationship between platelet indices and the presence and severity of AE.
Main Methods:
- A comparative study involving preschool children diagnosed with AE and age-matched healthy controls.
- Complete blood count and detailed platelet parameter analysis (MPV, PDW, PLT/MPV ratio) were performed.
- Statistical analysis was used to compare groups and assess correlations.
Main Results:
- Children with AE showed significantly higher MPV values (p = 0.003) compared to controls.
- Mean PDW (p = 0.025) and PLT/MPV ratio (p = 0.021) were significantly lower in children with AE.
- No statistically significant differences were found in white blood cell count, hemoglobin, MCV, RDW, or platelet counts between the groups.
- No correlation was observed between AE severity and MPV, PDW, or PLT/MPV ratio.
Conclusions:
- Elevated MPV and reduced PDW and PLT/MPV ratio in children with AE suggest an inflammatory state.
- Platelet parameters, specifically MPV, PDW, and PLT/MPV ratio, may serve as potential biomarkers for inflammation in pediatric AE.
- The severity of atopic eczema in preschool children is not associated with alterations in these platelet parameters.
Background:
Mean platelet volume has been frequently used as an inflammatory marker in various diseases associated with inflammation. In this study, we compared platelet parameter levels between preschool children with and without atopic eczema (AE).
Methods:
Preschool children with AE and age-matched healthy children were included in the study. Complete blood count was assessed in children with AE while platelet parameters were compared between children with and without AE.
Results:
One hundred twenty eight pediatric patients (78 boys, mean age: 14 months) diagnosed with AE and 128 healthy patients (71 boys, mean age: 12 months ) were included in the study. There were no statistically significant differences between the genders (p = 0.375) and ages (p = 0.273) of both groups. WBC (p = 0.952), Hb (p = 0.370), MCV (p = 0.314) and RDW values (p = 0.124), and platelet counts (p = 0.198) of both groups were similar. In the AE group, while the MPV value was found to be higher (p = 0.003), mean PDW value (p = 0.025) and PLT/MPV ratio were found to be lower (p = 0.021). In addition, there was no correlation between the severity of AE and MPV (rho; 0.1, p = 0.257), PDW (rho; -0.1, p = 0.269) and PLT/MPV (rho; 0.07, p = 0.432) ratio.
Conclusions:
In patients with AE, as a sign of inflammation, PDW value and PLT/MPV ratio decrease while MPV value increases. This study has also shown that there is no association between the severity of AE and platelet parameters.
