Heterogeneous activity of rodent and lagomorph parotid gland extracts on the hemocoagulation process

Anticoagulant properties of parotid glands belonging to four species of mammals (rat, mouse, rabbit and hare) were investigated on the hemostatic system of human being. Heterogeneous effects of the glycoconjugates extractable from different species were demonstrated by means of thromboelastography and hemocoagulation screening tests. In fact, glycoconjugates isolated from the rodent (rat and mouse) parotid glands changed all the thromboelastographic parameters and the hemocoagulation tests (Thrombin Time, Prothrombin Time, Partial Thromboplastin Time). Glycoconjugates extracted from the rabbit parotid gland strongly affected the thromboelastogram parameters in addition to the Partial Thromboplastin Time. Finally, glycoderivatives obtained from the hare parotid gland only influenced the Partial Thromboplastin Time.