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Updated: Apr 8, 2026
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Published on: January 10, 2017
A practical and highly sensitive C3N4-TYR fluorescent probe for convenient detection of dopamine
Hao Li1, Manman Yang, Juan Liu
1Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, PR China. zhkang@suda.edu.cn yangl@suda.edu.cn hhuang0618@suda.edu.cn.
Abstract:
The C3N4-tyrosinase (TYR) hybrid is a highly accurate, sensitive and simple fluorescent probe for the detection of dopamine (DOPA). Under optimized conditions, the relative fluorescence intensity of C3N4-TYR is proportional to the DOPA concentration in the range from 1 × 10(-3) to 3 × 10(-8) mol L(-1) with a correlation coefficient of 0.995. In the present system, the detection limit achieved is as low as 3 × 10(-8) mol L(-1). Notably, these quantitative detection results for clinical samples are comparable to those of high performance liquid chromatography. Moreover, the enzyme-encapsulated C3N4 sensing arrays on both glass slide and test paper were evaluated, which revealed sensitive detection and excellent stability. The results reported here provide a new approach for the design of a multifunctional nanosensor for the detection of bio-molecules.
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