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Related Concept Videos

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Related Experiment Video

Updated: Apr 8, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Radiation Testing of the GERD Stimulation Therapy System Using a Particle Accelerator.

Michael S Gossman1,2

  • 1Regulation Directive Medical Physics, Russell, KY, USA.

Neuromodulation : Journal of the International Neuromodulation Society
|June 30, 2015
PubMed
Summary
This summary is machine-generated.

The EndoStim Lower Esophageal Sphincter (LES) Stimulation System neurostimulators (EndoStim I and II) showed no performance changes when exposed to radiation from a particle accelerator. This indicates the devices can withstand direct radiation during cancer treatment.

Keywords:
EndoStim®GERDIPGimplantneurostimulatoroncologyradiation

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Area of Science:

  • Medical Devices
  • Radiation Oncology
  • Biomedical Engineering

Background:

  • Particle accelerators are used in cancer treatment.
  • Neurostimulators like EndoStim are implanted to treat conditions such as gastroesophageal reflux disease.
  • The potential impact of radiation exposure on implanted medical devices requires investigation.

Purpose of the Study:

  • To evaluate the performance of EndoStim neurostimulators under radiation exposure.
  • To determine if radiation from a particle accelerator affects EndoStim device function.
  • To assess the safety of using EndoStim during radiation therapy.

Main Methods:

  • Twelve EndoStim Lower Esophageal Sphincter (LES) Stimulation System neurostimulators (six EndoStim I, six EndoStim II) were tested.
  • Devices were programmed for passive and active stimulation modes.
  • Exposure to 18 MV Bremsstrahlung X-rays at 6 Gy/min up to a cumulative dose of 80 Gy was administered.

Main Results:

  • Device performance parameters including stimulation frequency, amplitude, pulse width, and voltage were monitored.
  • No significant changes in device operation or parameter magnitudes were observed.
  • All functional parameter changes remained within ±10% of baseline values.

Conclusions:

  • EndoStim I and II implantable pulse generators are resistant to X-ray radiation up to 18 MV.
  • The devices demonstrated immunity to radiation at dose rates up to 6 Gy/min and cumulative doses of at least 80 Gy.
  • EndoStim LES Stimulation System neurostimulators can withstand direct radiation exposure, supporting their use in patients undergoing radiation therapy.