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The Effect of HLA-DRB1 on Cholecystitis
Tawfik Jasim Mohammad Al-Marzook1, Batool Mutar Mahdi, Hyam Raouf
1Department of Microbiology, Al-Kindy College of Medicine, Baghdad University, Baghdad, Iraq,
Insights
This study found a genetic link between HLA-DRB1*0301 and cholecystitis, a common digestive disease. This specific gene variant appears to increase the risk of developing gallstone gallbladder inflammation.
Area of Science:
- Immunogenetics
- Gastroenterology
- Molecular Epidemiology
Background:
- Cholecystitis is a prevalent digestive disease with known risk factors like obesity and diabetes.
- Understanding genetic predispositions is crucial for disease prevention and management.
Purpose of the Study:
- To investigate the association between Human Leukocyte Antigen - DRB1 (HLA-DRB1) alleles and cholecystitis.
- To identify potential genetic markers for cholecystitis risk.
Main Methods:
- A case-control study involving 40 Iraqi Arab cholecystitis patients and 40 healthy controls.
- DNA typing using Polymerase Chain Reaction - Sequence Specific Oligonucleotide Probes (PCR-SSOP) to identify HLA-DRB1 alleles.
Main Results:
- An increased frequency of the HLA-DRB1*0301 allele was observed in cholecystitis patients compared to controls.
- Statistical analysis indicated a significant association (p=0.0442, OR=4.1111).
Conclusions:
- The HLA-DRB1*0301 allele is potentially associated with cholecystitis in the studied population.
- This finding suggests a genetic component contributing to cholecystitis development.
Background:
Cholecystitis is one of the major digestive diseases. Its prevalence is particularly high in some populations. Significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes.
Objective:
To determine the association between HLA-DRB1 and cholecystitis.
Methods:
This case-control study included forty Iraqi Arab patients who had cholecystitis with multiple calculi treated by cholecystectomy admitted in the surgical ward at Al-Kindy Teaching Hospital Baghdad between September -2013 to June -2014. The control group consisted of forty healthy volunteers among the staff of Al-Kindy College of Medicine. Control and cholecystitis patients groups were typed for identifying the DRB1* alleles using DNA-based methodology (PCR-SSOP).
Results:
There was an increased frequency of HLA-DRB1*0301 in patients with cholecystitis compared with healthy controls (p=0.0442, odd ratio=4.1111, 95% CI: 1.0372-16.2949).
Conclusion:
HLA-DRB1*0301, as a genetic factor, seems to have an association with cholecystitis.
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