Related Experiment Video
Updated: Apr 8, 2026
08:05
A Syngeneic Pancreatic Cancer Mouse Model to Study the Effects of Irreversible Electroporation
Published on: June 8, 2018
12.1K
Irreversible Electroporation Can Effectively Ablate Hepatocellular Carcinoma to Complete Pathologic Necrosis
Rex G Cheng1, Renuka Bhattacharya1, Matthew M Yeh2
1Department of Medicine, Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington.
Journal of Vascular and Interventional Radiology : JVIR
|June 30, 2015
Summary
Irreversible electroporation (IRE) effectively treats hepatocellular carcinoma (HCC), with explant pathology confirming complete tumor necrosis in most cases. Radiographic correlation supports IRE
Area of Science:
- Hepatobiliary surgery
- Interventional oncology
- Transplant surgery
Background:
- Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality.
- Irreversible electroporation (IRE) is an emerging ablation technique for HCC.
- Liver transplantation is a curative option for select HCC patients.
Observation:
- This study evaluated 6 HCC patients treated with IRE before liver transplant.
- Patients had Child-Pugh A or B cirrhosis.
- Tumor size ranged from 6-26 mm, with a median of 22 mm.
Findings:
- All treated HCCs showed complete radiographic response post-IRE.
- Pathologic examination of explants revealed complete necrosis in 5 out of 6 tumors.
- Minimal residual tumor (<5%) was found in one case, at the periphery of the treated area.
Implications:
- IRE demonstrates high efficacy in eradicating HCC, as confirmed by explant pathology.
- Radiographic findings correlate well with pathologic outcomes after IRE for HCC.
- IRE may be a valuable tool in the management of HCC patients awaiting liver transplantation.
