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Antibodies as a source of anti-infective peptides: an update

Walter Magliani1, Laura Giovati1, Tecla Ciociola1

  • 1Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.

Future Microbiology
|June 30, 2015
PubMed

This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune system and to the latest experimental evidence of Abs as a source of anti-infective and antitumor peptides derived from their complementarity determining regions and constant regions.

Keywords:
antibodiesantibody-derived anti-infective peptidesantibody-derived antitumor peptidesantibody-derived immunomodulatory peptidescryptidesmicrobicidal antibodiestherapeutic antibodies

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