Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.2K
Papillary Dermis01:11

Papillary Dermis

6.8K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.8K
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

5.6K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
5.6K
Reticular Dermis01:15

Reticular Dermis

5.5K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
5.5K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

3.9K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with thrombotic events among young adults in India, 2021-23: A multi-centric hospital-based matched case -control study.

The Indian journal of medical research·2026
Same author

Early psychotherapeutic interventions for posttraumatic stress responses in children and adolescents: A scoping review.

Journal of child and adolescent mental health·2026
Same author

Identifying electrode migration post cochlear implantation in children and its correlation with speech outcome.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same author

Promoting a Sense of Belonging Among Care-Experienced Young People: Insights From a Scoping Review.

Clinical child psychology and psychiatry·2026
Same author

Prevalence of gestational diabetes mellitus in India: The ICMR-INDIAB national study (ICMR-INDIAB-24).

The Indian journal of medical research·2025
Same author

Maternal and Fetal Outcomes in Pregnant Women Admitted to the Intensive Care Unit with A/H1N1pdm or SARS-CoV-2 Infection: A Retrospective Study.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2025

Related Experiment Video

Updated: Apr 8, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

885

Scleromyxedema: An Atypical Case.

Emy Thomas1, Anisha George1, Divya Deodhar2

  • 1Department of Dermatology, Christian Medical College, Ludhiana, India.

Indian Journal of Dermatology
|June 30, 2015
PubMed
Summary

Scleromyxedema, a rare skin disorder, typically involves mucin deposition and is often linked to paraproteinemia. This case highlights a patient with scleromyxedema lacking monoclonal gammopathy but presenting with eosinophilia.

Keywords:
Eosinophiliapapular mucinosisscleromyxedema

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

21.1K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

2.0K

Related Experiment Videos

Last Updated: Apr 8, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

885
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

21.1K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

2.0K

Area of Science:

  • Dermatology
  • Immunology
  • Rare Diseases

Background:

  • Scleromyxedema is a rare idiopathic disorder characterized by dermal mucin deposition and collagen increase.
  • Patients often exhibit associated paraproteinemia, typically monoclonal gammopathy.
  • The condition presents with a generalized papular eruption and can lead to significant morbidity.

Purpose of the Study:

  • To report a unique case of scleromyxedema.
  • To investigate the clinical presentation in the absence of monoclonal gammopathy.
  • To highlight associated peripheral eosinophilia in this specific presentation.

Main Methods:

  • Case report of a 59-year-old gentleman.
  • Clinical examination focusing on skin lesions, pruritus, and mobility.
  • Laboratory investigations including assessment for paraproteinemia and peripheral blood counts.

Main Results:

  • The patient presented with features consistent with scleromyxedema, including severe pruritus and scalp involvement.
  • Peripheral eosinophilia was noted.
  • Crucially, no monoclonal gammopathy was detected despite the scleromyxedema diagnosis.

Conclusions:

  • Scleromyxedema can occur in the absence of monoclonal gammopathy.
  • Peripheral eosinophilia may be a feature in some scleromyxedema cases.
  • This case expands the understanding of scleromyxedema's varied clinical and laboratory presentations.