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Updated: Apr 8, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Total Synthesis of Nominal Cyclocinamide B and Investigation into the Identity of the Cyclocinamides
Stephanie S Curzon1, Jessica M Garcia1, Joseph P Konopelski1
1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064.
Abstract:
The total synthesis of nominal cyclocinamide B, a cyclic peptide marine natural product, is reported together with an isomer of nominal cyclocinamide A. Initial attempts at the synthesis of the title compounds by inclusion of a turn inducer failed. However, direct synthesis succeeded in formation of the 14-membered cyclic peptide structure. Comparison of the data from all synthetic cyclocinamide A and B compounds with those of the natural products leads to the conclusion that the two natural products possess the same relative stereochemistry and that the true structures have not been defined.
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