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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

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Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
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Allergic Reactions02:06

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Overview
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Related Experiment Video

Updated: Apr 8, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Th22 cells in allergic disease.

Kilian Eyerich1, Stefanie Eyerich2

  • 1Department of Dermatology and Allergy, Technische Universität München, München, Germany ; Department of Dermatology and Allergy, Technical University Munich, Biedersteiner Straße 29, 80802 Munich, Germany.

Allergo Journal International
|June 30, 2015
PubMed
Summary
This summary is machine-generated.

This review explores Th22 cells, a specialized T helper cell subset. Th22 cells protect epithelial barriers and modulate tissue inflammation, playing a key role in allergic diseases.

Keywords:
IL-22T cellT helper cellTh22allergyatopic eczema

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Area of Science:

  • Immunology
  • T cell differentiation
  • Allergic diseases

Background:

  • T cell immunology is complex, with numerous newly identified subtypes.
  • Understanding the specific functions of these T helper cell subtypes is crucial.

Approach:

  • This review summarizes current knowledge on Th22 cells.
  • Focuses on their role in allergic disease pathogenesis and function.

Key Points:

  • Th22 cells are terminally differentiated T helper cells.
  • They secrete IL-22 and lack IL-4, IL-17, and IFN-γ.
  • Their primary functions include protecting epithelial barrier organs and modulating inflamed tissues.

Conclusions:

  • Th22 cells are important players in allergic diseases.
  • Further research is needed to fully elucidate their functions and therapeutic potential.