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Increased serum alkaline phosphatase activity in Behçet's disease
A Takeuchi1, H Haraoka, T Hashimoto
1Second Department of Medicine, Faculty of Medicine, University of Teikyo, Tokyo, Japan.
Clinical and Experimental Rheumatology
|November 1, 1989
Summary
Elevated serum alkaline phosphatase (Al-P) indicates active Behcet's disease (BD). This liver enzyme marker correlates with inflammation markers like erythrocyte sedimentation rate and C-reactive protein, aiding in BD activity assessment.
Area of Science:
- Biochemistry
- Immunology
- Rheumatology
Background:
- Behcet's disease (BD) is a chronic inflammatory disorder.
- Identifying reliable biomarkers for BD activity is crucial for patient management.
Purpose of the Study:
- To investigate the association between serum alkaline phosphatase (Al-P) levels and Behcet's disease activity.
Main Methods:
- Serum Al-P levels were measured in 213 patients with Behcet's disease.
- Al-P isoenzyme analysis was performed.
- Correlation with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) was assessed.
Main Results:
- Elevated serum Al-P levels were observed in 10.8% of BD patients.
- Al-P isoenzyme studies indicated an increased liver fraction.
- Increased Al-P levels showed a significant correlation with ESR and CRP.
Conclusions:
- Serum alkaline phosphatase is a potential indicator of Behcet's disease activity.
- Elevated Al-P, particularly the liver fraction, may reflect active inflammation in BD.
- Al-P serves as a valuable biomarker alongside ESR and CRP for monitoring BD disease activity.