Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions
Christian Schachtrup1, Jae Kyu Ryu2, Könül Mammadzada3
11] Gladstone Institute of Neurological Disease, University of California, San Francisco, California, USA. [2] Institute of Anatomy and Cell Biology, Department of Molecular Embryology, University of Freiburg, Freiburg, Germany.
Abstract:
Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-β signaling. Cleaved p75(NTR) interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-neuronal communication in response to profibrotic factors.
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