Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

2.7K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.7K
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

1.8K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.8K
Hormonal Regulation01:33

Hormonal Regulation

37.2K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
37.2K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

1.4K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.4K
Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers01:22

Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers

1.8K
α-Adrenergic antagonists, known as α-blockers, exert their effects by inhibiting α-adrenoceptors, leading to specific physiological actions. α1-blockers and α2-blockers have distinct pharmacological actions and therapeutic applications.
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally,...
1.8K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

4.5K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family Leaders Navigate Burden to Communicate Risk During Cascade Screening after Sudden Cardiac Death in the Young.

Public health genomics·2026
Same author

The Impact of Electronic Health Records on Family Physicians During Simulated Virtual Encounters: Exploratory Mixed Methods Study.

JMIR medical informatics·2026
Same author

Treatment resistant obesity among midlife women receiving care from a specialized weight management clinic.

Obesity pillars·2026
Same author

Accessing equitable menopause care in the contemporary NHS: a qualitative study of women's experiences.

The British journal of general practice : the journal of the Royal College of General Practitioners·2025
Same author

Menopause care for diverse communities: a qualitative study of GP clinician experiences.

The British journal of general practice : the journal of the Royal College of General Practitioners·2025
Same author

Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control.

Frontiers in endocrinology·2024

Related Experiment Video

Updated: Apr 8, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

24.6K

SELECTIVE HYPOALDOSTERONISM: A REVIEW.

Cory Wilczynski, Lisa Shah, Mary Ann Emanuele

    Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
    |June 30, 2015
    PubMed
    Summary

    Selective hypoaldosteronism (SH) causes hyperkalemia from low aldosterone. Increased physician awareness of SH is crucial for timely diagnosis and appropriate treatment of this rare condition.

    More Related Videos

    Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
    12:19

    Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

    Published on: June 27, 2015

    11.7K
    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
    08:35

    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

    Published on: May 26, 2022

    4.5K

    Related Experiment Videos

    Last Updated: Apr 8, 2026

    A Novel Method: Super-selective Adrenal Venous Sampling
    06:08

    A Novel Method: Super-selective Adrenal Venous Sampling

    Published on: September 15, 2017

    24.6K
    Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
    12:19

    Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

    Published on: June 27, 2015

    11.7K
    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
    08:35

    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

    Published on: May 26, 2022

    4.5K

    Area of Science:

    • Endocrinology
    • Internal Medicine

    Background:

    • Selective hypoaldosteronism (SH) is characterized by hyperkalemia due to diminished aldosterone secretion while maintaining normal cortisol levels.
    • A significant barrier to diagnosing SH is the lack of awareness among healthcare professionals.

    Purpose of the Study:

    • This review aims to consolidate current knowledge on the epidemiology, pathophysiology, etiology, clinical presentation, diagnostic approaches, and therapeutic strategies for SH.
    • To enhance the recognition and management of selective hypoaldosteronism.

    Main Methods:

    • A comprehensive literature search was conducted using PubMed and Ovid Medline databases.
    • The search focused on articles where hypoaldosteronism was a primary subject, including recent case reports and genetic studies.

    Main Results:

    • The available recent literature on selective hypoaldosteronism is notably scarce.
    • Few English-language review articles published within the last five years were identified; thus, case reports and genetic studies provide the most current information.

    Conclusions:

    • Elevating physician awareness of SH is expected to improve the identification of at-risk individuals.
    • Enhanced awareness will facilitate more informed decisions regarding the necessity and type of treatment for SH patients.