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Updated: Apr 8, 2026
Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
Oral Sucrose for Pain in Neonates During Echocardiography: A Randomized Controlled Trial
Nirav T Potana1, Ashish R Dongara, Somashekhar M Nimbalkar
1Departments of Pediatrics and *Physiology, Pramukhswami Medical College; and #Central Research Services, Charutar Arogya Mandal; Karamsad, Gujarat, India. Correspondence to: Prof Somashekhar Nimbalkar, Professor of Pediatrics, Department of Pediatrics, Pramukhswami Medical College, Karamsad-Anand, Gujarat 388 325. somu_somu@yahoo.com.
Objective:
To test the efficacy of oral sucrose in reducing pain/stress during echocardiography as estimated by Premature Infant Pain Profile score.
Design:
Double-blind, parallel-group, randomized control trial.
Setting:
Tertiary-care neonatal care unit located in Western India.
Participants:
Neonates with established enteral feeding, not on any respiratory support and with gestational age between 32 and 42 weeks requiring echocardiography.
Interventions:
Neonates in intervention group received oral sucrose prior to echocardiography.
Main Outcome Measures:
Assessment was done using Premature Infant Pain Profile score.
Results:
There were 104 examinations; 52 in each group. Baseline characteristics like mean gestational age (37.6 vs. 37.1), birth weight (2.20 vs. 2.08), and feeding status (Breastfeeding- 59.6% vs. 44.2%, paladai feeding- 13.5% vs. 13.5%, and gavage feeding- 26.9% vs. 42.3%) were comparable. The mean (SD) premature infant pain profile score was significantly higher in control group [(7.4 (3.78) vs. 5.2 (1.92), P <0.001].
Conclusion:
Oral sucrose significantly reduces pain, and is safe to administer to neonates.
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