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Related Experiment Video

Updated: Apr 8, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Bisphenol A: Human exposure and neurobehavior.

Vicente Mustieles¹, Rocío Pérez-Lobato¹, Nicolás Olea²

¹Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain.

Neurotoxicology

|July 1, 2015

Summary

Prenatal exposure to bisphenol A (BPA) may negatively impact child neurobehavior, including aggression and attention issues. More research is needed, but reducing BPA exposure during pregnancy is advisable.

Keywords:

Behavior Bisphenol A (BPA)Child Endocrine disruptors (EDCs)Human exposure Neurodevelopment

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Area of Science:

Environmental Health
Neuroscience
Pediatrics

Background:

Bisphenol A (BPA) is an environmental chemical with growing concerns regarding its effects on child development.
Research on BPA's impact on neurodevelopment is emerging, particularly focusing on prenatal and early childhood exposure.

Purpose of the Study:

To review and synthesize current scientific knowledge on the association between environmental BPA exposure and child cognitive/behavioral outcomes.
To assess the impact of BPA exposure during pregnancy and childhood on neurobehavioral development.

Main Methods:

Systematic review of scientific publications available up to March 2015.
Literature search conducted using the MEDLINE/PubMed database.
Analysis of studies examining the relationship between BPA exposure and child neurobehavioral outcomes.

Main Results:

Eight out of twelve reviewed articles reported an association between BPA exposure and altered neurobehavior in children.
Reported neurobehavioral effects include aggression, attention deficit, hyperactivity disorder, depression, and anxiety.
Prenatal BPA exposure appears to be a critical window for neurodevelopmental disruption, with potential sex-dependent effects.

Conclusions:

Evidence suggests prenatal BPA exposure may adversely affect children's neurobehavioral functioning.
Further human studies are necessary to confirm the association between BPA exposure and health outcomes.
Women planning or undergoing pregnancy should be informed about measures to minimize BPA exposure.