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Hyperlactatemia in type 2 diabetes: Can physical training help?

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Type 2 diabetes is linked to high lactate levels. Regular physical activity can help normalize lactate in patients, unlike metformin treatment.

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Exercise Physiology

Background:

  • Type 2 diabetes is frequently associated with hyperlactatemia, reduced aerobic capacity, and impaired lactate transport.
  • Elevated lactate levels are implicated in insulin resistance development and progression, though mechanisms are unclear.
  • The causal relationship between high lactate and type 2 diabetes remains to be fully elucidated.

Purpose of the Study:

  • To review the role of lactate in type 2 diabetes.
  • To explore the impact of physical activity on lactate metabolism in type 2 diabetic patients.
  • To compare the efficacy of physical training versus metformin in managing lactate levels.

Main Methods:

  • Literature review focusing on lactate's role in type 2 diabetes.
  • Analysis of studies investigating physical activity interventions.
  • Examination of research on metformin's effect on lactate.

Main Results:

  • Physical training may decrease lactate production and enhance lactate transport and clearance.
  • Elevated lactate levels are a common feature in type 2 diabetes.
  • Metformin, a common type 2 diabetes drug, does not effectively reduce lactate levels.

Conclusions:

  • Lactate is a critical molecule in type 2 diabetes pathophysiology.
  • Regular physical activity is a promising therapeutic strategy for normalizing lactate levels in type 2 diabetes.
  • Physical training offers advantages over metformin in managing lactate-associated complications in type 2 diabetes.