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Related Experiment Video

Updated: Apr 8, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Intrasphenoidal Rathke's cleft cyst.

Manish K Kasliwal1, Sumeet G Dua2, Aparna Harbhajanka3

  • 1Department of Neurosurgery, Rush University Medical Center, Suite 855, 1725 West Harrison Street, Chicago, IL 60612, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|July 1, 2015
PubMed
Summary

This study details an extremely rare intrasphenoidal Rathke's cleft cyst (RCC). Diagnosis is challenging, impacting surgical options for this uncommon intrasphenoidal Rathke's cleft cyst.

Keywords:
CraniopharyngiomaRadiologyRathke’s cleft cystSphenoid

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Area of Science:

  • Neurosurgery
  • Endocrinology
  • Pathology

Background:

  • Rathke's cleft cysts (RCCs) are typically intrasellar or intra-suprasellar.
  • Extrasellar RCCs are uncommon, with intrasphenoidal locations being exceptionally rare.

Observation:

  • This report presents a rare case of an intrasphenoidal Rathke's cleft cyst.
  • Only two previous cases of intrasphenoidal RCC have been documented in medical literature.

Findings:

  • Preoperative diagnosis of intrasphenoidal RCC is difficult due to its unusual location.
  • Characteristic radiological features are often absent, complicating identification.

Implications:

  • The rare location of intrasphenoidal RCC may restrict surgical management options.
  • Transsphenoidal surgery might be limited to biopsy and drainage of the cyst contents.
  • Increased awareness is crucial for appropriate patient management and surgical planning.